General Drug Information and Indications

Prednisolone sodium succinate injectable for acute anti-inflammatory therapy, shock, and severe allergic reactions. Prednisolone sodium succinate injectable (water-soluble fast-acting corticosteroid). Mechanism: glucocorticoid receptor agonist → anti-inflammatory and immunosuppressive via NF-κB and AP-1 suppression, phospholipase A2 inhibition. Rapid IV/IM onset for acute inflammatory and shock situations. 4× potency of cortisol. Key information Prednisolone sodium succinate injectable. Refrigerate reconstituted solution. IV or IM. Short-acting soluble corticosteroid.

How to Give this Medication

IV: dilute in compatible IV fluid; Administer IV slowly; rapid infusion may cause adverse reactions. IM: inject deep IM. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Side Effects

IV rapid injection: cardiovascular effects (give slowly). HPA axis suppression. PU/PD. Immunosuppression. GI ulceration. Behavioral changes (excitability).

Precautions

For animals See prednisolone. Monitor for GI ulceration; use with caution in animals with GI disease. Avoid in pregnant animals. Do not use concurrently with other NSAIDs or corticosteroids. Administer IV slowly. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Corticosteroid injectable — Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Wear gloves. Administered by veterinary staff.

Overdose

Contact your veterinarian. Corticosteroid overdose causes metabolic disturbances and immunosuppression.

Solu-delta Cortef dosage forms

ProductStrengthFormSizeType
SOLU-DELTA CORTEF 100 MG INJECTABLE: PREDNISOLONE SODIUM SUCCINATE100 MGInjectable1Commercial
SOLU-DELTA CORTEF 500 MG INJECTABLE: PREDNISOLONE SODIUM SUCCINATE500 MGInjectable1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Corticosteroids in Animals (https://www.merckvetmanual.com/pharmacology/inflammation/corticosteroids-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)