Sotalol Hcl

Class III antiarrhythmic (beta-blocker + potassium channel blocker) for ventricular arrhythmias in dogs and cats. Class III antiarrhythmic with beta-adrenergic blocking properties (sotalol HCl). Mechanism: blocks potassium channels (IKr, IKs) → prolongs action potential duration and QT interval → increased ventricular refractoriness; also non-selective beta-blocker → negative chronotropy and dromotropy. Pure d-sotalol (class III only); d,l-sotalol (class II + III) used clinically. Key information Class III antiarrhythmic (non-selective beta-blocker). Monitor ECG — QT prolongation risk. Do not abruptly discontinue. Dose adjust in renal impairment. Store at room temperature.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Administer at consistent times. Do not crush. ECG monitoring recommended during initiation. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose. Never abruptly stop this medication.

QT prolongation → torsade de pointes (most serious adverse effect). Bradycardia, AV block, hypotension. Negative inotropy. Bronchospasm. Exercise intolerance. Hypokalemia increases arrhythmia risk. ECG monitoring required.

For animals Continuous ECG monitoring required — risk of proarrhythmia (torsade de pointes). Correct hypokalemia and hypomagnesemia before initiating (increases QT risk). Avoid concurrent QT-prolonging drugs. Reduce dose or extend interval in renal impairment. — dose-reduce in renal impairment. Do not abruptly discontinue. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antiarrhythmic — very dangerous to children (cardiac arrhythmias). Store securely away from children. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian or emergency clinic immediately. Sotalol overdose causes life-threatening arrhythmias (QT prolongation, torsades de pointes). Cardiac monitoring required.