Sucralfate

Cytoprotective antiulcer agent for GI ulcers in horses and small animals; binds ulcerated mucosa; adjunct for equine glandular gastric disease. Cytoprotective antiulcer agent. Mechanism: in acidic gastric environment, sucrose octasulfate dissociates → aluminum hydroxide + sucrose octasulfate polymer → viscous paste adheres to ulcerated mucosa → physical barrier against HCl, pepsin, and bile; adsorbs bile acids; stimulates mucosal PGE2 synthesis (cytoprotective). Acts locally — not systemically absorbed. Key information Binds to ulcer base — optimal effect when given on empty stomach and separate from other medications (can bind and reduce absorption of other drugs — separate by 2 hours). Store at room temperature. GI protectant — slurry form for horses.

Oral tablets or suspension: administer on an empty stomach (30–60 min before feeding or other medications) for maximum efficacy — requires acid environment for activation. Shake well before each use. suspension. Tablets may be crushed and dissolved in water to make slurry. Administer 2 hrs before other oral medications. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Administer on an empty stomach, separate from other medications by 2 hours.

Constipation (most common adverse effect — aluminum component). GI: nausea (uncommon). Drug interactions: reduces absorption of many drugs (fluoroquinolones, tetracyclines, phenytoin, digoxin — separate by 2 hrs). Aluminum accumulation with renal failure (prolonged use).

For animals Administer 2 hrs before or after other oral medications (adsorbs drugs). Avoid concurrent antacids (requires acidic environment for activation). Reduce dose or extend interval in renal impairment. — aluminum accumulation with prolonged use in renal failure. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Cytoprotective — generally safe to handle. Wash hands thoroughly with soap and water after handling. Keep out of reach of children.

Contact your veterinarian. Sucralfate is not systemically absorbed — overdose is very unlikely to cause toxicity. May cause constipation.