Sulfadiazine Sodium/trimethoprim, Aloe, & Dmso Spray

Compounded trimethoprim-sulfadiazine combination antibiotic spray for topical wound and skin infection management in horses; broad-spectrum antibacterial activity. Sulfonamide antimicrobial (sulfadiazine). Mechanism: competitive antagonist of PABA → inhibits dihydropteroate synthase → blocks bacterial/protozoal folate synthesis. Bacteriostatic alone; when combined with trimethoprim or pyrimethamine, synergistic sequential blockade. High CSF penetration — useful for CNS infections and EPM treatment. Key information See SMZ-TMP. Usually given in combination with sulfonamide.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Ensure adequate water intake. Complete full course. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Ensure your animal drinks adequate water. Complete the full course.

GI: anorexia, vomiting, diarrhea. Renal: crystalluria (ensure adequate hydration). Hematologic: bone marrow suppression with prolonged use (CBC monitoring). KCS in dogs. Hepatotoxicity. Hypersensitivity (fever, rash). Folate depletion.

For animals Ensure adequate hydration. Reduce dose or extend interval in renal impairment. Monitor CBC periodically with prolonged use. Use with caution in pregnant animals. Avoid sulfonamide-hypersensitive patients. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Sulfonamide — inform doctor if sulfa-allergic. Wash hands thoroughly with soap and water after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Overdose causes GI signs, bone marrow suppression, and folate deficiency with prolonged excess. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.