General Drug Information and Indications

Sulfamethazine bolus for susceptible bacterial infections, coccidiosis, and enteric disease in cattle. Sulfonamide antimicrobial bolus (sulfamethazine). Mechanism: competitive PABA antagonist → inhibits dihydropteroate synthase → blocks bacterial folate synthesis (bacteriostatic). Sustained-release bolus for cattle. Long-acting sulfonamide for respiratory disease and coccidiosis control in livestock. Key information Sulfamethazine bolus for cattle/poultry. Administer with adequate water. Food animal withdrawal times required. Sulfonamide — avoid in sulfa-sensitive animals.

How to Give this Medication

Oral bolus (ruminants): administer per oral bolus gun. Oral drench: dissolve in water; administer via drench gun. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Ensure adequate water intake. Complete the course.

Side Effects

GI: anorexia, GI irritation. Renal: crystalluria, urolithiasis. Hematologic: bone marrow suppression. KCS in dogs. Hepatotoxicity (rare). Withdrawal times (food animals). Hypersensitivity.

Precautions

For animals Observe food animal withdrawal times for milk and meat. Adequate hydration. Reduce dose or extend interval in renal impairment. Monitor CBC periodically with prolonged use. Dogs: KCS monitoring. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Sulfonamide — inform doctor if sulfa-allergic. Wash hands thoroughly with soap and water after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Overdose

Contact your veterinarian. Sulfonamide overdose causes crystalluria and GI effects. Ensure water intake.

Sulmet Bolus dosage forms

ProductStrengthFormSizeType
SULMET BOLUS 5 GM BOLUS: SULFAMETHAZINE5 GM—1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)