Sulpiride

Dopamine antagonist for agalactia and reproductive enhancement in mares; suppresses dopaminergic inhibition of prolactin release; stimulates milk production. Selective dopamine D2 receptor antagonist / benzamide antipsychotic. Mechanism: blocks D2 receptors in pituitary lactotrophs → relieves dopaminergic inhibition of prolactin secretion → increases prolactin levels → stimulates mammary gland development and milk production. Poor blood-brain barrier penetration at low doses. Used in mares for fescue agalactia and reproductive enhancement. Key information Dopamine antagonist — used for equine agalactia/fescue toxicosis. Store at room temperature. May cause galactorrhea. Extrapyramidal side effects possible.

Oral: Administer orally via dose syringe placed at the back of the tongue, or mix into a small amount of palatable feed. mixed into grain or via syringe. Administer at consistent times. Monitor prolactin response. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: diarrhea, increased motility. Galactorrhea/mammary development (intended for agalactia mares). Behavioral: sedation or agitation. QT prolongation (rare). Generally well tolerated in mares at equine doses.

For animals Monitor prolactin response (mammary development, milk production). Drug interaction: QT-prolonging drugs — avoid. Not approved for use in food-producing animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Dopamine antagonist — Wash hands thoroughly with soap and water after handling. after handling. Prolactin-elevating effects with chronic exposure. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Sulpiride overdose may cause galactorrhea, sedation, and extrapyramidal effects.