Tanovea-ca1 Inj

Rabacfosadine (RRPA) for relapsed/refractory canine non-Hodgkin's lymphoma. Novel antineoplastic (rabacfosadine / RRPA). Mechanism: pro-nucleotide analogue that delivers active PME-ATP directly into lymphoma cells via phosphoramidase activation → incorporates into DNA during replication → DNA damage → apoptosis. Selective lymphocyte cytotoxicity. IV infusion; for relapsed/refractory canine lymphoma. Key information Rabacfosadine — antineoplastic (lymphoma). CYTOTOXIC — handle with chemotherapy precautions. Refrigerate. Dogs only. Monitor CBC and pulmonary function. Pulmonary fibrosis risk.

IV infusion: dilute in 0.9% NaCl; administer over 30–60 min using appropriate cytotoxic handling protocols (gloves, gown, eye protection). Pre-medicate with antiemetic. Use within 4 hrs of reconstitution. Store refrigerated (2–8°C); do not freeze. (unreconstituted). If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Myelosuppression: neutropenia, thrombocytopenia (nadir 7–10 days — monitor CBC). GI: vomiting, diarrhea, anorexia. Pulmonary toxicity: dyspnea, cough, pleural effusion (serious — may require dose reduction or discontinuation). Alopecia. Infusion reactions.

For animals Monitor CBC periodically with prolonged use. (nadir 7–10 days post-infusion). Monitor for pulmonary toxicity (dyspnea, cough, pleural effusion) — dose-reduce or discontinue if noted. Monitor renal function, hydration status, and urine output. Avoid in pregnant animals. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. CYTOTOXIC. Wear gloves, gown, and eye protection. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Do not handle if pregnant or breastfeeding. Dispose of waste per cytotoxic protocols. Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention.

Contact your veterinary oncologist immediately. Rabacfosadine overdose causes pulmonary toxicity and bone marrow suppression.