Temaril-p

Combination trimeprazine/prednisolone for pruritic conditions in dogs; antihistamine and corticosteroid combination. Combination antipruritic (trimeprazine tartrate + prednisolone). Trimeprazine: phenothiazine derivative H1 antihistamine with anticholinergic and mild sedative properties; prednisolone: glucocorticoid receptor agonist. Combined H1 antihistamine + corticosteroid for synergistic antipruritic effect in canine allergic pruritus. Key information Trimeprazine/prednisolone combination. Antihistamine + corticosteroid. Dogs only. Store at room temperature. Corticosteroid component — adrenal suppression with prolonged use. Avoid use in animals with active infections.

Oral tablets (dogs): Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Administer twice daily initially, then once daily. Tablets may be split. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Sedation, anticholinergic effects (trimeprazine — dry mouth, urinary retention). HPA suppression, PU/PD, immunosuppression, GI ulceration (prednisolone). Extrapyramidal signs (phenothiazine component). Laminitis risk (horses).

For animals Phenothiazine/corticosteroid combination. Avoid in hypovolemic patients, epileptic patients (lowers seizure threshold), and horses (phenothiazine risk — penile prolapse). Monitor for GI ulceration; use with caution in animals with GI disease. Avoid live vaccines; taper corticosteroid on discontinuation. Do not use concurrently with other NSAIDs or corticosteroids. NOT recommended in horses. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Phenothiazine/corticosteroid combination — wear gloves (contact dermatitis risk from phenothiazine). Corticosteroid: avoid prolonged skin contact. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Prednisolone component of this combination can cause GI signs, immunosuppression, and metabolic disturbances with overdose. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.