Terbinafine Tab

Allylamine antifungal for dermatophytosis and systemic fungal infections in dogs, cats, and horses. Allylamine antifungal (terbinafine HCl). Mechanism: inhibits squalene epoxidase → blocks ergosterol biosynthesis early in the pathway → squalene accumulation (toxic) and ergosterol depletion → fungicidal activity (fungistatic vs. some Candida). Active against dermatophytes, some dimorphic fungi, and Malassezia. Oral or topical. Hepatically metabolized. Key information Oral or topical antifungal. Monitor hepatic function with oral use. Store at room temperature. Drug interactions: CYP2D6 inhibitor. Prolonged treatment course (6–12 weeks for systemic fungal infections).

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Tablets may be crushed and mixed into food. Administer once daily. Topical (cream/solution): apply thin layer to affected area once or twice daily. Long treatment course required (weeks to months for dermatophytosis). Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Complete the full antifungal course (may take weeks to months).

GI: diarrhea, vomiting, anorexia (most common). Hepatotoxicity (monitor liver enzymes with systemic use — rare but possible). Skin: rash, urticaria (hypersensitivity). Taste disturbances. Generally better tolerated than azole antifungals.

For animals Monitor liver enzymes with prolonged use. Drug interaction: terbinafine inhibits CYP2D6 — increases tricyclic antidepressant and beta-blocker levels. Not approved for use in food-producing animals. Use with caution in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Allylamine antifungal — Wash hands thoroughly with soap and water after handling. after handling. Generally safe. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Overdose causes GI signs and potential liver effects. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.