Thyrotropin Releasing Hormone (trh/protirelin Acetate)

TRH stimulation test diagnostic agent for evaluation of pituitary function and diagnosis of PPID in horses. TRH — hypothalamic tripeptide hormone for diagnostic stimulation test. Mechanism: stimulates anterior pituitary TSH and prolactin release; in PPID diagnosis, also stimulates aberrant ACTH release from pars intermedia → exaggerated plasma ACTH response confirms PPID diagnosis. IV administration for dynamic stimulation test in horses. Key information Protirelin acetate (TRH) — diagnostic test agent for equine PPID. Refrigerate. Single-use. IV injection. Used with ACTH stimulation testing protocol.

IV injection (diagnostic test): administer as rapid IV bolus over 30 sec. Collect plasma ACTH samples at time 0 and 10 min post-injection. Horse should be standing and unstressed before sampling. Store refrigerated (2–8°C); do not freeze. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Transient: mild sedation, defecation, salivation, sweating, and transient tachycardia (horses — within minutes of IV injection). These side effects are brief (resolve within 10–30 min). Generally safe as diagnostic test.

For animals TRH stimulation test — diagnostic use only. Administer IV dose as rapid bolus. Record plasma ACTH at 0 and 10 min post-injection for PPID diagnosis. Side effects (defecation, yawning, sweating) are expected and transient. For people handling this medication Administered by veterinary professionals only. No specific human precautions for caregivers beyond normal hygiene.

Contact your veterinarian. TRH diagnostic agent — administered by veterinary staff. Contact vet if adverse signs develop.