Ticarcillin/clavulanate Semen Extender

Extended-spectrum penicillin/clavulanate combination for treatment of beta-lactamase-producing gram-negative infections; semen extender formulations for equine breeding. Extended-spectrum antipseudomonal penicillin (ticarcillin disodium ± clavulanate potassium). Mechanism: binds PBPs → inhibits bacterial cell wall peptidoglycan synthesis (bactericidal). Carboxypenicillin class — extended spectrum to Pseudomonas aeruginosa, Proteus, some Klebsiella. Clavulanate is a beta-lactamase inhibitor extending spectrum to resistant organisms. Used IM/uterine in mares. Key information Extended-spectrum penicillin/clavulanate for equine reproductive tract. Refrigerate reconstituted solution. Intrauterine infusion: culture before treatment. High sodium content with ticarcillin.

IV or IM (ticarcillin) or intrauterine (mares): IV — dilute in compatible solution; infuse over 30 min. Intrauterine: dilute in sterile saline (200–500 mL); infuse via sterile catheter using aseptic technique. Store refrigerated (2–8°C); do not freeze. (reconstituted). If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Hypersensitivity (penicillin class). Electrolyte: high sodium load with high-dose IV. Platelet dysfunction (carboxypenicillins). GI: diarrhea. Phlebitis (IV). Hypokalemia (large doses). Superinfection.

For animals Avoid in beta-lactam-hypersensitive animals. Monitor electrolytes (high Na+ load with extended-spectrum penicillins). Reduce dose or extend interval in renal impairment. High doses: platelet dysfunction risk. Intrauterine mares: use diluted solution with aseptic technique. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Extended-spectrum penicillin — penicillin allergy risk. Wear gloves. Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately.

Contact your veterinarian. Extended-spectrum penicillin overdose causes GI signs and high sodium load with large doses. Penicillin allergy reactions possible.