Ticarcillin Sodium/clavulanate Potassium
General Drug Information and Indications
Extended-spectrum penicillin/beta-lactamase inhibitor (ticarcillin/clavulanate) for susceptible gram-negative infections in horses; intrauterine use for equine endometritis.
Extended-spectrum antipseudomonal penicillin (ticarcillin disodium ± clavulanate potassium). Mechanism: binds PBPs → inhibits bacterial cell wall peptidoglycan synthesis (bactericidal). Carboxypenicillin class — extended spectrum to Pseudomonas aeruginosa, Proteus, some Klebsiella. Clavulanate is a beta-lactamase inhibitor extending spectrum to resistant organisms. Used IM/uterine in mares.
Key information
Extended-spectrum penicillin/clavulanate for equine reproductive tract. Refrigerate reconstituted solution. Intrauterine infusion: culture before treatment. High sodium content with ticarcillin.
How to Give this Medication
IV or IM (ticarcillin) or intrauterine (mares): IV — dilute in compatible solution; infuse over 30 min. Intrauterine: dilute in sterile saline (200–500 mL); infuse via sterile catheter using aseptic technique. Store refrigerated (2–8°C); do not freeze. (reconstituted).
If a dose is missed
This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.
Side Effects
Hypersensitivity (penicillin class). Electrolyte: high sodium load with high-dose IV. Platelet dysfunction (carboxypenicillins). GI: diarrhea. Phlebitis (IV). Hypokalemia (large doses). Superinfection.
Precautions
For animals
Avoid in beta-lactam-hypersensitive animals. Monitor electrolytes (high Na+ load with extended-spectrum penicillins). Reduce dose or extend interval in renal impairment. High doses: platelet dysfunction risk. Intrauterine mares: use diluted solution with aseptic technique.
For people handling this medication
Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Extended-spectrum penicillin — penicillin allergy risk. Wear gloves. Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately.
Overdose
Contact your veterinarian. Extended-spectrum penicillin overdose causes GI signs and high sodium load with large doses. Penicillin allergy reactions possible.
Ticarcillin Sodium/clavulanate Potassium dosage forms
| Product | Strength | Form | Size | Type |
|---|---|---|---|---|
| TICARCILLIN DISODIUM/CLAVULANATE POTASSIUM 8 GM/60 GM PACKING OINTMENT | 8 GM/60 GM | Ointment | 1 | Compound |
| TICARCILLIN DISODIUM/POTASSIUM CLAVULANATE 62MG/ML SOLUTION - 50 ML | 62 MG/ML | Solution | 50 ML | Compound |
| TICARCILLIN DISODIUM/POTASSIUM CLAVULANATE UTERINE 3.1 GM POWDER | 3.1 GM | Powder | 1 | Compound |
| TICARCILLIN SODIUM/CLAVULANATE POTASSIUM 100 MG POWDER | 100 MG | Powder | 1 | Compound |
| TICARCILLIN SODIUM/CLAVULANATE POTASSIUM 200 MG POWDER | 200 MG | Powder | 1 | Compound |
| TICARCILLIN SODIUM/CLAVULANTE POTASSIUM 3.1 GM / 55 ML GEL | 3.1 GM/55 ML | Gel | 1 | Compound |
Sources
This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Penicillins Use in Animals (https://www.merckvetmanual.com/pharmacology/antibacterial-agents/use-of-penicillins-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)