General Drug Information and Indications

Tobramycin ophthalmic solution for bacterial conjunctivitis, corneal ulcers, and ocular surface infections. Tobramycin 0.3% ophthalmic solution. Mechanism: aminoglycoside — 30S ribosomal binding → bactericidal protein synthesis inhibition. Active against gram-negative aerobic pathogens including Pseudomonas. Standard ophthalmic antibiotic formulation. Key information Tobramycin ophthalmic ointment/solution. For ophthalmic use only. Store at room temperature.

How to Give this Medication

Ophthalmic solution: Instill into the conjunctival sac; avoid touching dropper tip to eye or periocular tissue. q4–6h. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Side Effects

Ophthalmic: transient stinging/burning upon instillation. Contact sensitization. Ototoxicity near ruptured TM. Minimal systemic absorption.

Precautions

For animals See tobramycin ophthalmic. Verify tympanic membrane integrity for otic use. For people handling this medication Wash hands thoroughly with soap and water after handling. Tobramycin ophthalmic — avoid human eye contact. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Wash hands thoroughly with soap and water after handling.

Overdose

Contact your veterinarian. Flush eye with clean water if excessive product was applied. Systemic toxicity from ophthalmic use is unlikely.

Tobrex dosage forms

ProductStrengthFormSizeType
TOBREX 0.3% OPH OINT: TOBRAMYCIN SULFATE—Ointment1Commercial
TOBREX 0.3% OPH SOLN: TOBRAMYCIN SULFATE—Solution1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Aminoglycosides Use in Animals (https://www.merckvetmanual.com/pharmacology/antibacterial-agents/aminoglycosides-use-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)