Toltrazuril/dmso

General Drug Information and Indications

Compounded toltrazuril (anticoccidial) formulated in DMSO for enhanced bioavailability; treatment of coccidiosis and Sarcocystis neurona in foals and horses. Triazinetrione anticoccidial (toltrazuril). Mechanism: blocks mitochondrial electron transport and nuclear division in coccidial merozoites and schizonts (Eimeria spp., Sarcocystis) → impairs energy production and parasite replication. Active against multiple intracellular stages. Single or double dose orally for coccidiosis prophylaxis/treatment in foals and neonatal livestock. Key information Antiprotozoal for Coccidia. Store at room temperature. Administer per label — dosing varies by species. Safe in foals. Single-dose or short course.

How to Give this Medication

Oral solution: Administer orally. May be given with food to improve compliance and reduce GI upset. or Administer orally via dose syringe placed at the back of the tongue, or mix into a small amount of palatable feed. via dose syringe. Shake well before each use. well. Administer as a single or double dose per protocol. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Side Effects

Generally very well tolerated. GI: mild, transient diarrhea. No significant adverse effects documented at labeled doses in horses and ruminants.

Precautions

For animals Complete full course. Not approved for use in food-producing animals. at extra-label doses. Use with caution in pregnant animals. (use in foals — mares' colostrum exposure: timing relative to birth). For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antiprotozoal — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Overdose

Contact your veterinarian. Toltrazuril overdose typically causes GI signs. Contact vet for guidance.

Toltrazuril/dmso dosage forms

ProductStrengthFormSizeType
TOLTRAZURIL/DMSO 150 MG/6% PER ML SUSPENSION - 250 ML150 MG/6% PER MLSuspension250 MLCompound

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Compounding pharmacy formulation; Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)