Tranexamic Acid

Antifibrinolytic for hemorrhage control; hyperfibrinolytic bleeding in horses and small animals; perioperative hemostasis. Antifibrinolytic agent (tranexamic acid). Mechanism: competitively inhibits activation of plasminogen to plasmin by blocking the lysine-binding sites on plasminogen → reduces fibrin clot dissolution → hemostatic effect. More potent than aminocaproic acid. Used IV or topically to control surgical and traumatic hemorrhage in horses and small animals. Key information Antifibrinolytic. IV: infuse slowly. Monitor for thrombosis. Used for wound healing and epistaxis in horses.

IV: dilute in 0.9% NaCl or D5W; Administer IV slowly; rapid infusion may cause adverse reactions. over 10–20 min. Oral: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Topical (wound): apply soaked gauze directly to bleeding surface. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

GI: nausea, vomiting, diarrhea. Thrombotic events (excessive antifibrinolysis in hypercoagulable state). Seizures (IV — dose-dependent; use caution in seizure history). Hypotension (rapid IV infusion). Visual disturbances (rare).

For animals Avoid in patients with thromboembolic disease or DIC. Reduce dose or extend interval in renal impairment. — reduce dose in renal impairment. Drug interaction: concurrent estrogens increase clotting risk. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Antifibrinolytic — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian immediately. Overdose may cause nausea, vomiting, or thrombotic events. Supportive care is administered by veterinary staff.