General Drug Information and Indications

Buffered aspirin (tri-buffered acetylsalicylic acid) for anti-inflammatory, analgesic, antipyretic, and antiplatelet use in horses and dogs; GI buffering reduces gastric irritation. Buffered aspirin (acetylsalicylic acid with alkaline buffering agents). Mechanism: aspirin irreversibly inhibits COX-1 and COX-2 → reduces prostaglandin synthesis; magnesium/calcium carbonate buffers reduce gastric acid exposure of aspirin → less gastric irritation. Antiplatelet, anti-inflammatory, analgesic, and antipyretic effects. Key information Buffered aspirin — see aspirin entry. Do not use in cats. Administer with food to reduce GI effects.

How to Give this Medication

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Tablets may be split. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Always give with food. Do not use in cats.

Side Effects

GI: gastric irritation (reduced vs. plain aspirin due to buffer). Platelet dysfunction (irreversible COX-1). Salicylism (overdose): vomiting, hyperpyrexia. Cats: toxic — avoid.

Precautions

For animals See aspirin. Avoid in cats. Monitor for GI ulceration; use with caution in animals with GI disease. Platelet inhibition — discontinue 7 days before surgery. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Buffered aspirin — salicylate. Keep away from children. Do not use in cats.

Overdose

Contact your veterinarian. Buffered aspirin overdose causes GI ulceration and bleeding. Toxic to cats. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.

Tri-buff Asa Tab dosage forms

ProductStrengthFormSizeType
TRI-BUFF ASA TAB 325MG325 MGTablet—Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Nonsteroidal Anti-inflammatory Drugs in Animals (https://www.merckvetmanual.com/pharmacology/inflammation/nonsteroidal-anti-inflammatory-drugs-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)