Triamcinolone Acetonide

Potent fluorinated corticosteroid for intra-articular, intralesional, or systemic anti-inflammatory therapy; equine joint injections and dermatologic conditions. Fluorinated glucocorticoid — triamcinolone acetonide. Mechanism: potent glucocorticoid receptor agonist → anti-inflammatory via NF-κB suppression and annexin-1 induction → inhibits phospholipase A2 → reduces arachidonic acid products. Acetonide ester for depot injection (intra-articular, intradermal); 16α,17α-acetonide ring prevents mineralocorticoid effects. ~5× potency of cortisol. Key information Corticosteroid — intermediate duration. Intra-articular use: aseptic technique critical. Avoid frequent IA injections — cartilage damage risk. HPA suppression can last 4–6 weeks. Competition withdrawal required.

IM (depot): inject deep IM into large muscle mass. Intra-articular: strict aseptic technique; clip, prep site; aspirate joint fluid; inject slowly into joint space. Intradermal: administer intradermally for dermatologic conditions. Post-injection rest 24–48 hrs (intra-articular). Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Same as triamcin. Corticosteroid class effects: HPA suppression, immunosuppression, PU/PD, muscle atrophy, GI ulceration, delayed healing. Laminitis risk (horses). Post-injection synovitis (intra-articular). Repeated intra-articular injections: cartilage erosion, joint infection risk.

For animals Laminitis risk in horses — avoid in at-risk patients. Intra-articular: aseptic technique; max 3–4 injections/year per joint. Avoid in pregnant animals. Monitor for GI ulceration; use with caution in animals with GI disease. Adrenal suppression with repeated use. Do not use concurrently with other NSAIDs or corticosteroids. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Corticosteroid — avoid prolonged skin contact. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Wear gloves when handling.

Contact your veterinarian. Triamcinolone overdose causes immunosuppression and metabolic disturbances.