Tribrissen 400

Trimethoprim-sulfadiazine combination antibiotic for bacterial infections in horses and small animals. Potentiated sulfonamide combination (trimethoprim-sulfadiazine 400 mg). Mechanism: sequential dual blockade of folate synthesis — sulfadiazine inhibits dihydropteroate synthase (PABA antagonist); trimethoprim inhibits dihydrofolate reductase → bactericidal synergy. 1:5 trimethoprim:sulfonamide ratio. Oral administration for horses. Key information Trimethoprim/sulfadiazine — see SMZ-TMP entry. Ensure adequate water intake. Sulfonamide — avoid in sulfa-sensitive animals.

Oral powder (horses): mix into a small amount of grain or water. Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Complete full course. Ensure adequate water intake. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Mix with feed. Ensure adequate water. Complete the full course.

GI: anorexia, vomiting, diarrhea. Renal: crystalluria. CBC: bone marrow suppression. KCS (dogs). Hepatotoxicity. Sulfonamide hypersensitivity. Folate depletion.

For animals Ensure adequate hydration. Reduce dose or extend interval in renal impairment. Monitor CBC periodically with prolonged use. KCS monitoring (dogs). Monitor liver enzymes with prolonged use. Use with caution in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Potentiated sulfonamide — inform doctor if sulfa-allergic. Wash hands thoroughly with soap and water after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. TMS overdose causes GI signs, crystalluria, and blood cell effects.