Trichlormethiazide

Thiazide diuretic for edema; combined with dexamethasone (Naquasone) for laminitis in horses. Thiazide diuretic (trichlormethiazide). Mechanism: inhibits Na-Cl cotransporter in distal convoluted tubule → reduces tubular sodium reabsorption → diuresis. Also vasodilatory (direct relaxation of arteriolar smooth muscle). Combined with dexamethasone (Naquasone) for treatment of laminitis-associated edema via combined diuretic/anti-inflammatory action. Key information Thiazide diuretic (Naquasone, Trichlor). Monitor electrolytes. May be combined with dexamethasone. Used for edema in horses. Store at room temperature.

Oral bolus (cattle — Naquasone): administer via oral bolus gun. Ensure adequate water intake. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Thiazide diuretic effects: hypokalemia, hyponatremia, dehydration. GI: vomiting, diarrhea. Photosensitivity. With dexamethasone (Naquasone): combined corticosteroid + diuretic adverse effects — laminitis risk, immunosuppression, electrolyte disturbances.

For animals See trichlormethiazide + dexamethasone. Laminitis risk (corticosteroid). Monitor electrolytes (diuretic + corticosteroid). Avoid in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Thiazide diuretic/dexamethasone — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Thiazide overdose causes electrolyte imbalances (low sodium and potassium). Signs include weakness, muscle cramps, and irregular heartbeat. IV fluid support may be needed.