Trichlormethiazide/dexamethasone

Combination thiazide diuretic (trichlormethiazide) and corticosteroid (dexamethasone) for management of laminitis-associated edema in horses; historically marketed as Naquasone. Combination diuretic + corticosteroid for laminitis management. Trichlormethiazide: thiazide inhibitor of Na-Cl cotransporter → mild diuresis and edema reduction. Dexamethasone: glucocorticoid receptor agonist → anti-inflammatory, reduces prostaglandin-mediated inflammation. Trade name Naquasone; used for laminitis-associated digital edema. Key information Thiazide diuretic (Naquasone, Trichlor). Monitor electrolytes. May be combined with dexamethasone. Used for edema in horses. Store at room temperature.

Oral bolus (cattle — Naquasone): administer via oral bolus gun. Ensure adequate water intake. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If the next dose is due within a few hours, skip the missed dose and resume the regular schedule. Never give a double dose.

Combined diuretic + corticosteroid: electrolyte disturbances (hypokalemia most significant — monitor K+), HPA suppression, laminitis risk (horses — corticosteroid component), PU/PD, immunosuppression, GI ulceration. Dehydration with excessive diuresis.

For animals See trichlormethiazide + dexamethasone. Laminitis risk (corticosteroid). Monitor electrolytes (diuretic + corticosteroid). Avoid in pregnant animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Corticosteroid + diuretic — wear gloves. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Minimize skin contact.

Contact your veterinarian. Thiazide overdose causes electrolyte imbalances (low sodium and potassium). Signs include weakness, muscle cramps, and irregular heartbeat. IV fluid support may be needed.