Tricide Powder Powder Pkt

Tromethamine-EDTA chelating solution for ear canal decontamination and antibiotic potentiation in otitis; effective against Pseudomonas. Tromethamine-EDTA (edetate disodium) solution for ear decontamination. Mechanism: EDTA chelates divalent cations (Mg2+, Ca2+) from bacterial outer membrane (especially gram-negative, Pseudomonas) → destabilizes and permeabilizes outer membrane → potentiates antibiotics 2–4 fold by enhancing their entry into gram-negative bacteria. Tromethamine (TRIS) provides alkaline pH enhancing EDTA chelation. Key information Tris-EDTA — antimicrobial potentiator. For topical/otic use — enhances antibiotic penetration into bacterial biofilm. Not antimicrobial alone. Use with appropriate antibiotic. Safe for ear use.

Otic lavage: instill solution into ear canal; gently flush and allow contact for 5–10 min; drain and repeat as needed. Administer 2 hrs before antibiotic ear medication to maximize antibiotic penetration. Store at room temperature; protect from light. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Generally non-toxic and well tolerated for ear lavage. Mild stinging upon instillation. EDTA component: irritating to eyes (avoid contact). Systemic absorption minimal. Provides no antimicrobial activity itself — potentiates antibiotics.

For animals EDTA chelation — use only as directed for otic decontamination. Enhances antibiotic penetration of gram-negative organisms. Not a standalone treatment — follow with appropriate antibiotic therapy. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Avoid inhaling sprays or aerosols. Keep out of reach of children. Tris-EDTA ear lavage — generally safe. Avoid eye contact. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention.

Contact your veterinarian. Tris-EDTA is a potentiator — very low toxicity on its own. Used with antibiotics for ear treatment.