Trifexis Canine 60.1-120 Lbs 60.1-120 Lbs Tablet

Spinosad/milbemycin oxime for flea prevention and heartworm/intestinal parasite control in dogs. Combination oral antiparasitic (spinosad + milbemycin oxime). Spinosad: spinosyn natural product → activates nicotinic acetylcholine receptors (nAChR) and GABA receptors in insects → insect CNS hyperexcitation → rapid flea kill; milbemycin oxime: macrocyclic lactone → GluCl channel potentiation → heartworm prevention and intestinal nematode control. Key information Spinosad/milbemycin — combination ectoparasiticide/heartworm prevention. Dogs only. Monthly chewable — administer with food (spinosad requires food). Not for cats. Use caution in MDR1/ABCB1 mutation breeds.

Oral chewable tablet: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or immediately after. Monthly dosing. Use correct weight-band product. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember, always with food, and resume monthly administration.

GI: vomiting (most common — give with food), diarrhea, anorexia, lethargy. CNS: tremors, ataxia, seizures (rare — isoxazoline component). Lufenuron: minimal adverse effects. Generally well tolerated at labeled doses.

For animals Use with caution in dogs with seizure history. Not for puppies <8 weeks. Not approved for use in food-producing animals. Give with food to reduce vomiting. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Combination antiparasitic — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Contact your veterinarian. Trifexis overdose may cause vomiting, tremors, and neurological signs (spinosad/milbemycin components). Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.