Trifluridine Opthalmic Solution

Topical antiviral (trifluridine/viroptic) ophthalmic drops for equine and feline herpetic keratitis. Nucleoside analogue antiviral ophthalmic (trifluridine 1% solution). Mechanism: thymidine analogue — competes with thymidine for incorporation into viral DNA by viral (and to lesser extent host) thymidylate synthase and DNA polymerase → defective viral DNA → inhibits viral replication. Active against herpesviruses (FHV-1, EHV). More topically effective than acyclovir for ocular herpes. Key information Ophthalmic antiviral. Refrigerate. For ophthalmic use only. Frequent dosing protocol (every 2–4 hours initially). May cause local ocular irritation.

Ophthalmic solution: Instill into the conjunctival sac; avoid touching dropper tip to eye or periocular tissue. Instill 1 drop into affected eye(s) q2h (up to 9 drops/day) initially; reduce to q4h once re-epithelialization occurs. Store refrigerated (2–8°C); do not freeze. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Ophthalmic: transient stinging/burning upon instillation. Superficial punctate keratopathy (with prolonged use — corneal toxicity). Palpebral edema, hyperemia. Stromal edema (rare). Systemic absorption minimal.

For animals Topical ophthalmic only. Frequent dosing schedule required (q2h initially) — compliance essential. Corneal epithelial toxicity with prolonged use — limit to labeled duration. For people handling this medication Wash hands thoroughly with soap and water after handling. Antiviral ophthalmic — avoid human eye contact. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Wash hands thoroughly with soap and water after handling.

Contact your veterinarian if eye irritation persists. Systemic toxicity from ophthalmic trifluridine is very unlikely.