Tryptophan/magnesium Glycinate/thiamine Hydrochloride

Combination supplement providing L-tryptophan (serotonin precursor) and magnesium glycinate for management of anxiety, nervousness, and muscle tension in horses; often includes thiamine as cofactor. Essential amino acid and serotonin precursor (L-tryptophan). Mechanism: crosses blood-brain barrier → converted to 5-HTP by tryptophan hydroxylase → decarboxylated to serotonin (5-HT). Increased CNS serotonin → anxiolytic, calming behavioral effects. Often combined with magnesium glycinate (GABA-A receptor co-agonist) and thiamine (B1; neurological support) for equine calmers. Key information Combined calming supplement for horses. Store at room temperature. Administer with feed. May cause mild sedation. Competition rules may apply — check USEF withdrawal.

Oral supplement: mix into grain or feed. Administer 1–2 hrs before anticipated stressful event for best effect. May be given daily for chronic behavioral management. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If you forget a day, simply resume the normal schedule the next day. Missing an occasional dose of this supplement is unlikely to cause harm.

CNS sedation (serotonin precursor). GI: mild GI upset at high doses. Serotonin syndrome (with concurrent serotonergic drugs — use with caution). Generally well tolerated at supplement doses. Overdose: CNS toxicity.

For animals Drug interaction: avoid concurrent MAOIs and serotonergic drugs. Use as part of a comprehensive behavioral management plan, not as sole therapy. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Amino acid supplement — generally safe. Wash hands thoroughly with soap and water after handling.

Contact your veterinarian. L-tryptophan overdose may cause sedation and GI signs. Serotonin effects possible with very large doses.