Tucoprim

General Drug Information and Indications

Trimethoprim-sulfadoxine oral antibiotic for susceptible bacterial respiratory, urinary, and soft tissue infections in horses. Potentiated sulfonamide (trimethoprim-sulfadoxine). Mechanism: trimethoprim inhibits dihydrofolate reductase; sulfadoxine inhibits dihydropteroate synthase → sequential folate synthesis blockade → bactericidal synergy. Long-acting formulation — twice-daily dosing in horses due to sulfadoxine's extended half-life. Key information Trimethoprim/sulfadiazine — see SMZ-TMP entry. Equine oral powder. Mix with feed. Ensure adequate water intake.

How to Give this Medication

Oral paste (horses): administer via dose syringe into mouth. Tablets (small animals): Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Ensure adequate water intake. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Mix with feed. Ensure adequate water intake. Complete the full course.

Side Effects

GI: anorexia, vomiting, diarrhea. Renal: crystalluria (hydration essential). Hematologic: CBC monitoring. KCS (dogs). Hepatotoxicity. Sulfonamide hypersensitivity (fever, skin rash). Folate depletion.

Precautions

For animals Adequate hydration essential. Reduce dose or extend interval in renal impairment. Monitor CBC periodically with prolonged use. KCS monitoring (dogs). Monitor liver enzymes with prolonged use. Use with caution in pregnant animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Potentiated sulfonamide — inform doctor if sulfa-allergic. Wash hands thoroughly with soap and water after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Overdose

Contact your veterinarian. TMS overdose causes GI signs and crystalluria.

Tucoprim dosage forms

Product	Strength	Form	Size	Type
TUCOPRIM 200 GM 67 MG/333 MG PER GM POWDER: TRIMETHOPRIM 67 MG AND SULFADIAZINE 333 MG PER GRAM	200 GM	Powder	1	Commercial
TUCOPRIM 2000 GM 67 MG/333 MG PER GM POWDER: TRIMETHOPRIM 67 MG AND SULFADIAZINE 333 MG PER GRAM	2000 GM	Powder	1	Commercial
TUCOPRIM 400 GM 67 MG/333 MG PER GM POWDER: TRIMETHOPRIM 67 MG AND SULFADIAZINE 333 MG PER GRAM	400 GM	Powder	1	Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)