Uniprim
General Drug Information and Indications
Oral trimethoprim-sulfadiazine for susceptible bacterial infections in horses; respiratory, urinary, and soft tissue infections.
Potentiated sulfonamide powder (trimethoprim 67 mg + sulfadiazine 333 mg per 5g sachet/scoop). Mechanism: dual sequential blockade of bacterial folate synthesis — sulfadiazine blocks PABA utilization; trimethoprim blocks dihydrofolate reduction → bactericidal synergy at 20:1 sulfonamide:TMP ratio. Equine oral powder for respiratory, urinary, and soft tissue infections.
Key information
Trimethoprim/sulfadiazine equine oral powder. Mix with sweet feed or molasses. Ensure adequate water intake. Loading dose recommended.
How to Give this Medication
Oral powder (horses): weigh and add to a small amount of carrier feed (grain or applesauce); ensure complete consumption. Administer once or twice daily as directed. Ensure adequate water intake. Store at room temperature; protect from light.
If a dose is missed
Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Mix with feed and ensure adequate water intake. Complete the full course.
Side Effects
GI: anorexia, soft feces, diarrhea. Crystalluria (ensure adequate hydration). Hematologic: CBC monitoring with prolonged use. KCS in dogs. Hepatotoxicity. Sulfonamide hypersensitivity. Folate depletion. Diarrhea in horses (uncommon but monitor hindgut flora).
Precautions
For animals
Horses: adequate water intake essential (crystalluria prevention). Reduce dose or extend interval in renal impairment. Monitor CBC periodically with prolonged use. KCS monitoring (dogs). Monitor liver enzymes with prolonged use. Use with caution in pregnant animals.
For people handling this medication
Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Potentiated sulfonamide powder — inform doctor if sulfa-allergic. Avoid inhaling powder. Wash hands thoroughly with soap and water after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.
Overdose
Contact your veterinarian. TMS overdose causes GI signs and crystalluria. Ensure adequate water intake.
Uniprim dosage forms
| Product | Strength | Form | Size | Type |
|---|---|---|---|---|
| UNIPRIM 200 GM 67 MG/333 MG PER GM POWDER: METHOPRIM 67 MG AND SULFADIAZINE 333 MG PER GM | 200 GM | Powder | 1 | Commercial |
| UNIPRIM 2000GM 67MG TRIMETHOPRIM/333MG SULFADIAZINE PER GRAM POWDER: TRIMETHOPRIM/SULFADIAZINE | 2000 GM | Powder | 1 | Commercial |
| UNIPRIM 37.5 GM POWDER PACKET | 37.5 GM | Powder | 1 | Commercial |
| UNIPRIM 400 GM 67 MG/333 MG PER GM POWDER: METHOPRIM 67 MG AND SULFADIAZINE 333 MG PER GM | 400 GM | Powder | — | Commercial |
| UNIPRIM PACKET 67 MG/333 MG PER GRAM POWDER: TRIMETHOPRIM 67 MG AND SULFADIAZINE 333 MG PER GM | 67 MG | Powder | 1 | Commercial |
| UNIPRIM POWDER (TRIMETH/SULFA) - 200GM | 200 GM | Powder | 1 | Commercial |
| UNIPRIM POWDER 1200 GRAMS | — | Powder | 1 | Commercial |
| UNIPRIM POWDER 2000 GM | 2000 GM | Powder | 1 | Commercial |
| UNIPRIM POWDER 67MG/333MG (TRIMETH/SULFADIAZINE) | 67 MG | Powder | 1 | Commercial |
Sources
This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)