Vetoryl

Trilostane (3β-HSD inhibitor) for hyperadrenocorticism (Cushing's disease) in dogs. 3β-HSD inhibitor (trilostane). Mechanism: competitively inhibits 3β-hydroxysteroid dehydrogenase (3β-HSD) enzyme in adrenal cortex → blocks conversion of pregnenolone to progesterone → inhibits cortisol, aldosterone, and adrenal androgen synthesis. Treats PDH and ADH (hyperadrenocorticism) in dogs. FDA-approved. Once or twice daily oral capsule. Key information Trilostane — adrenocortical inhibitor for PDH Cushing's disease in dogs. Store at room temperature. Monitor cortisol (ACTH stimulation test at 10-day, 4-week, 12-week intervals). Administer with food. Risk of hypoadrenocorticism — know signs of Addisonian crisis.

Oral capsules: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Wear gloves when handling — teratogenic. Do not open or crush capsules. Administer at consistent times. Monitor with ACTH stimulation test 10–14 days after starting or dose change (test 4–6 hrs after administration). Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Do not double the dose. If vomiting occurs around the dose, contact your veterinarian before giving the next dose.

Adrenal insufficiency (most serious — especially at higher doses or with illness/stress; always provide emergency corticosteroid and emergency plan). GI: lethargy, anorexia, vomiting, diarrhea (common, especially initially). Electrolyte abnormalities (low sodium, high potassium — Addisonian-like). Monitor electrolytes and cortisol levels regularly.

For animals Critical safety monitoring required: measure ACTH stimulation test (4–6 hrs post-pill, 10–14 days after starting or dose change) to avoid adrenal insufficiency. Provide emergency corticosteroid instructions to owners. Stress dosing: administer prednisolone for surgery, illness, or significant stress. Avoid in pregnant animals. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Trilostane (adrenal enzyme inhibitor) — wear gloves; do not break or crush capsules. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Teratogenic. Do not handle if pregnant. Can affect human adrenal function with prolonged skin contact. Keep out of reach of children.

Contact your veterinarian immediately. Trilostane overdose can trigger an Addisonian crisis (hypoadrenocorticism): weakness, vomiting, collapse, low blood pressure, and abnormal electrolytes. This is a medical emergency requiring IV fluids and supportive care.