Vetribute - Bute Tabs

Phenylbutazone (NSAID) oral granules/solution for pain and inflammation in horses. Phenylbutazone oral NSAID formulation (granules or paste for horses). Mechanism: non-selective COX-1 and COX-2 inhibitor → reduces prostaglandin and thromboxane synthesis → anti-inflammatory, analgesic, and antipyretic. Pyrazolone derivative. Most widely used equine NSAID. Key information Phenylbutazone — see phenylbutazone entry. Oral tablets or liquid. Do not use in food horses.

See phenylbutazone. Horses — IV: administer slowly into jugular vein. Oral granules: mix into grain. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember, always with feed. Do not double the dose.

GI: gastric and right dorsal colonic ulceration (horses). Renal: azotemia (dehydrated patients). Perivascular injection necrosis (IM/SQ routes — IV or oral only in horses). Hepatotoxicity. Hematologic: aplastic anemia, leukopenia (dogs — toxic species, avoid). Do not combine with other NSAIDs or corticosteroids.

For animals Horses: IV route only (IM causes severe tissue necrosis). Monitor for GI ulceration; use with caution in animals with GI disease. Monitor renal function, hydration status, and urine output. Do not use concurrently with other NSAIDs or corticosteroids. HIGHLY TOXIC in dogs (aplastic anemia, leukopenia) — avoid use in dogs. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Phenylbutazone NSAID — aplastic anemia risk with chronic human exposure. Wear gloves when handling. Avoid inhalation of powder/paste. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Keep out of reach of children.

Contact your veterinarian or emergency clinic immediately. Phenylbutazone overdose causes severe GI and kidney damage.