General Drug Information and Indications

Hydroxyethyl starch (HES) synthetic colloid for IV volume replacement and oncotic support. Hydroxyethyl starch (HES) 6% colloidal plasma expander. Mechanism: large molecular weight polymers (130–450 kDa) remain intravascular → maintain colloid oncotic pressure and expand intravascular volume. Maximum recommended dose to reduce coagulopathy risk. Used for resuscitation and treatment of hypoproteinemia in horses and small animals. Key information Hetastarch colloid IV solution. See hetastarch entry. Limit to 20 mL/kg/day. Monitor for coagulopathy.

How to Give this Medication

IV: administer via IV catheter as CRI or bolus; do not exceed maximum daily dose. Infuse over 15–30 min for rapid volume expansion. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Side Effects

Coagulopathy (dose-dependent — reduces Factor VIII, VWF, prolongs aPTT). Acute kidney injury (controversial; use caution in renal insufficiency). Volume overload. Pruritus (delayed). Anaphylaxis (rare). Follow dosing limits to reduce coagulopathy risk.

Precautions

For animals Maximum dose limits (≤20 mL/kg/day). Monitor coagulation with repeated dosing. Avoid in patients with coagulopathy, severe anemia, or renal failure. Not approved for use in food-producing animals. For people handling this medication Administered by veterinary professionals only. No specific human precautions for caregivers beyond normal hygiene.

Overdose

Contact your veterinarian. Hetastarch overdose causes coagulopathy and fluid overload. Managed by veterinary staff.

Vetstarch dosage forms

ProductStrengthFormSizeType
VETSTARCH 6 % IV: HYDROXYETHYL STARCH——1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)