Vfend

Voriconazole for equine keratomycosis and systemic fungal infections; broad-spectrum triazole with excellent corneal penetration. Triazole antifungal (voriconazole). Mechanism: inhibits fungal CYP51 (lanosterol 14α-demethylase) → ergosterol biosynthesis blockade → fungal membrane disruption. Second-generation triazole with broader spectrum than fluconazole (including Aspergillus, Fusarium, resistant Candida). Excellent corneal penetration in horses — drug of choice for equine keratomycosis. IV or oral. Key information Voriconazole — see voriconazole entry. Refrigerate oral solution. Drug interactions — potent CYP inhibitor. Monitor hepatic function.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer on an empty stomach for optimal absorption. for best absorption (or consistently with small amount of food). Separate from antacids and dairy by 1 hr. IV (extra-label): dilute in 0.9% NaCl; infuse over 1–3 hrs. Ophthalmic (compounded, equine): instill into conjunctival sac. Minimize UV exposure in horses during treatment. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Complete the full antifungal course.

GI: vomiting, diarrhea, anorexia. Hepatotoxicity (monitor liver enzymes). CNS: visual disturbances (hallucinations in humans — less reported in animals). Photosensitivity (especially horses — UV-induced skin reactions; limit sun exposure). Cardiovascular: QT prolongation. Numerous CYP2C9/CYP3A4 drug interactions.

For animals Monitor liver enzymes with prolonged use. Monitor renal function, hydration status, and urine output. Numerous CYP2C9/CYP3A4 drug interactions — check all concurrent medications. Avoid in pregnant animals. Photosensitivity in horses — limit UV exposure during therapy; squamous cell carcinoma risk with prolonged use. Drug of choice for equine keratomycosis — excellent corneal penetration. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Triazole antifungal — Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Teratogenic. Wear gloves. Numerous drug interactions — inform your doctor if handling regularly. Photosensitivity.

Contact your veterinarian. Voriconazole overdose causes liver toxicity and GI signs.