General Drug Information and Indications

Chloramphenicol for serious bacterial infections in dogs, cats, and horses where other antibiotics are inadequate. Chloramphenicol oral capsules/tablets. Mechanism: reversibly binds 50S ribosomal subunit → inhibits peptidyl transferase → bacteriostatic inhibition of protein synthesis. Active against gram-positive, gram-negative, anaerobes, Rickettsia, intracellular organisms. Risk of fatal aplastic anemia in humans via skin exposure — handle with gloves. Key information Chloramphenicol palmitate (oral). HUMAN SAFETY: Aplastic anemia risk — wear gloves. Not for food-producing animals. Monitor CBC.

How to Give this Medication

Oral capsules: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Wear gloves when handling — aplastic anemia risk to humans. Do not crush without PPE. Ophthalmic ointment: apply ribbon to conjunctival sac. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Wear gloves when handling. Complete the full course.

Side Effects

Myelosuppression: reversible dose-dependent bone marrow suppression. Human exposure hazard (aplastic anemia — wear gloves, do not allow owner contact). Cats: prolonged half-life → severe GI and bone marrow toxicity. GI: vomiting, diarrhea, anorexia.

Precautions

For animals See chloramphenicol. CONTRAINDICATED in neonates (gray syndrome). Use with caution in hepatic impairment. Numerous drug interactions. Bone marrow suppression monitoring essential. For people handling this medication SERIOUS HUMAN HEALTH HAZARD: Chloramphenicol can cause fatal irreversible aplastic anemia in humans — even with minimal skin contact. Wear chemical-resistant gloves at ALL times. Do NOT allow owners to handle without gloves. Avoid all contact with mucous membranes. {EYE} {WASH} after any contact. {PREG} Keep out of reach of children. If exposure occurs, inform your physician immediately.

Overdose

Contact your veterinarian immediately. Chloramphenicol overdose causes bone marrow suppression. Requires monitoring and supportive care.

Viceton dosage forms

ProductStrengthFormSizeType
VICETON 1 GM TABLET: CHLORAMPHENICOL1 GMTablet1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)