Vitamin A&d, Zinc Oxide & Chlorhexidine Ointment
General Drug Information and Indications
Treatment/prevention of vitamin A deficiency; night blindness; reproductive performance; immune function; wound healing.
Fat-soluble vitamin (retinol, retinyl acetate/palmitate). Mechanism: retinol oxidized to retinoic acid → binds nuclear retinoic acid receptors (RAR/RXR) → regulates gene transcription for cell differentiation, growth, immune function, and vision (rhodopsin synthesis). Required for corneal epithelial integrity, reproductive function, and immune competence.
Key information
Topical antiseptic only. OTOTOXIC — never instill in ears if eardrum integrity uncertain. Avoid contact with eyes. Not for IV use. Concentrations >2% can cause tissue damage. Incompatible with soaps/detergents (inactivated).
How to Give this Medication
Oral: mix into feed. Administer with food to reduce GI adverse effects. Injectable (oil-based): administer IM; warm to room temperature before injection. Administer as directed — do not exceed recommended dose (hypervitaminosis A risk). Store at room temperature; protect from light.
If a dose is missed
Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.
Side Effects
Hypervitaminosis A (overdose): bone fragility (cervical spondylosis in cats), alopecia, desquamation, hepatotoxicity, teratogenicity. GI: vomiting, anorexia (overdose). Safe at recommended supplemental doses.
Precautions
For animals
Hypervitaminosis A with excessive supplementation: cervical spondylosis in cats (irreversible spinal changes), bone fragility, alopecia, hepatotoxicity. Avoid in pregnant animals. at high doses (teratogenic). Do not supplement vitamin A in animals with adequate dietary intake.
For people handling this medication
Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Vitamin A — avoid ingestion of concentrated supplements (hypervitaminosis A). Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. High-dose vitamin A is teratogenic. Keep out of reach of children.
Overdose
If excessive product was applied, wash the area thoroughly with mild soap and water. Contact your veterinarian if the animal shows any signs of irritation, lethargy, tremors, or other unusual behavior. If ingested, contact your veterinarian. Chlorhexidine is toxic if swallowed — causes GI irritation and possible GI bleeding. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.
Vitamin A&d, Zinc Oxide & Chlorhexidine Ointment dosage forms
| Product | Strength | Form | Size | Type |
|---|---|---|---|---|
| VITAMIN A&D, ZINC OXIDE & CHLORHEXIDINE OINTMENT 28%/10%/1% | 28%/10%/1% | Ointment | 1 | Compound |
Sources
This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)