Yobine

Yohimbine (alpha-2 antagonist) for reversal of xylazine-induced sedation in dogs and cats. Alpha-2 adrenergic receptor antagonist (yohimbine HCl). Mechanism: competitive antagonist at alpha-2 adrenergic receptors → reverses CNS and peripheral effects of xylazine (alpha-2 agonist) by displacing it from receptors → reversal of sedation, analgesia, muscle relaxation, and bradycardia. Used for reversal of xylazine in dogs, cats, and horses. Shorter half-life than xylazine — may need redosing. Key information Yohimbine — alpha-2 antagonist reversal agent. IV: administer slowly — seizures with rapid injection. Refrigerate. Reverses xylazine. Short duration — may need to repeat.

IV or IM injection (reversal of xylazine). IV (slow): administer slowly over 1–2 min — too rapid injection causes tachycardia and excitement. IM: administer into large muscle mass. Have a calm, quiet environment ready for recovery. May repeat if re-sedation occurs. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Cardiovascular: tachycardia, hypertension (reversal of alpha-2 vasodilation). CNS: excitement, tremors, anxiety, muscle trembling (alpha-2 reversal). Salivation. Excessive reversal may unmask pain. Short half-life → renarcotization possible if xylazine blood levels transiently exceed yohimbine levels. Respiratory: rate increases.

For animals Short half-life — may need redosing if xylazine blood levels outlast yohimbine. Rapid reversal may unmask pain or cause excitement — have environment calm and safe. Avoid in patients with cardiac arrhythmias. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Alpha-2 antagonist — Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. If accidentally injected, may cause tachycardia and hypertension. Seek medical attention. Keep out of reach of children.

Contact your veterinarian. Yohimbine (reversal agent) overdose causes agitation, rapid heart rate, and seizures. Medical emergency.