Zactran
Call to order(859) 281-9511General Drug Information and Indications
Gamithromycin (long-acting macrolide) for bovine respiratory disease; single-dose treatment.
Long-acting macrolide antibiotic (gamithromycin). Mechanism: binds 50S ribosomal subunit → inhibits bacterial protein synthesis and translocation. Extremely long lung half-life (>90 hrs) with high pulmonary tissue:plasma concentration ratio → sustained activity at site of respiratory infection. Single-dose IM injection for bovine respiratory disease. Also anti-inflammatory properties.
Key information
Gamithromycin — long-acting macrolide. Single injection. Beef withdrawal: 35 days. Do not use in animals within 35 days of slaughter. For BRD treatment/control.
How to Give this Medication
IM injection: administer deep IM in the neck. Single dose. Maximum injection volume per site: 10 mL (cattle), 2.5 mL (swine). Store at room temperature; protect from light.
If a dose is missed
This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.
Side Effects
Injection site reactions (pain, swelling — common with IM injection; may persist as nodule). GI: decreased feed intake. Rare: anaphylaxis. Prolonged withdrawal times for food animals. Respiratory signs if aspirated.
Precautions
For animals
Observe food animal withdrawal times for milk and meat. Not for use in horses intended for human consumption. IM injection site reaction is expected.
For people handling this medication
Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Macrolide injectable — wear gloves. Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.
Overdose
Contact your veterinarian. Gamithromycin single-injection product — contact vet if dosing error occurred.
Zactran dosage forms
| Product | Strength | Form | Size | Type |
|---|---|---|---|---|
| ZACTRAN 150MG/ML INJECTABLE: GAMITHROMYCIN | 150 MG/ML | Injectable | 1 | Commercial |
Sources
This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)