Zantac

Ranitidine (H2-receptor antagonist) for gastric ulcers and GI hypersecretion in horses and small animals; prokinetic activity. H2 receptor antagonist (ranitidine HCl). Mechanism: competitively blocks H2 receptors on gastric parietal cells → reduces histamine-stimulated HCl secretion. Also inhibits acetylcholine esterase → prokinetic effect via increased acetylcholine in ENS. Less potent CYP450 inhibitor than cimetidine. Now largely replaced by PPIs. Key information Ranitidine — H2 blocker (discontinued in humans; still used in veterinary medicine). Fewer interactions than cimetidine. Store at room temperature.

Oral tablets: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. IV: dilute in 0.9% NaCl; Administer IV slowly; rapid infusion may cause adverse reactions. over 5–10 min. Administer q8–12h. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

GI: constipation or diarrhea (uncommon). CNS: confusion (rare — less than cimetidine). CYP450 drug interactions (less than cimetidine). Rare: hepatotoxicity, arrhythmias. Generally well tolerated.

For animals See ranitidine. Reduce dose or extend interval in renal impairment. Prokinetic effect via acetylcholinesterase inhibition. Fewer drug interactions than cimetidine. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). H2 blocker — generally safe. Wash hands thoroughly with soap and water after handling. Keep out of reach of children.

Contact your veterinarian. Ranitidine (H2 blocker) overdose causes GI signs. Rarely serious. Contact your veterinarian or a veterinary emergency clinic immediately if you believe your animal has received an overdose. Bring the medication label and note the approximate amount given.