Zirgan Gel

Ganciclovir ophthalmic gel for treatment of acute herpetic keratitis in cats and horses. Ganciclovir ophthalmic gel 0.15% (antiviral). Mechanism: phosphorylated by viral kinases to active ganciclovir triphosphate → competitive inhibitor of viral DNA polymerase → chain termination → inhibits herpesvirus DNA replication. Gel formulation for sustained contact time with cornea. Active against FHV-1 (cats) and EHV (horses). More convenient than trifluridine for outpatient use (5×/day). Key information Ganciclovir ophthalmic gel. Refrigerate. For ophthalmic use only. Antiviral for herpetic keratitis. Apply as directed.

Ophthalmic gel: apply approximately 1 cm ribbon into the lower conjunctival sac 5 times daily until ulcer heals, then 3 times daily for 7 more days. Store refrigerated (2–8°C); do not freeze. If a dose is missed Apply the missed dose as soon as you remember. If it is almost time for the next application, skip it and resume the normal schedule. Do not apply extra product to compensate.

Ophthalmic: transient blurred vision, eye irritation, stinging. Superficial punctate keratopathy (with prolonged use). Conjunctival hyperemia. Eye pruritus. Systemic absorption minimal.

For animals Topical ophthalmic only. Frequent dosing required (5×/day initially). Active against FHV-1 and EHV. Convenient gel formulation vs. trifluridine. For people handling this medication Wash hands thoroughly with soap and water after handling. Antiviral ophthalmic — avoid human eye contact. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Wash hands thoroughly with soap and water after handling.

Contact your veterinarian. Ganciclovir ophthalmic — systemic toxicity very unlikely from topical use.