Zonisamide Cap

Broad-spectrum anticonvulsant for refractory epilepsy in dogs and cats; adjunct to phenobarbital. Sulfonamide-derived anticonvulsant (zonisamide). Mechanism: multiple mechanisms — blocks voltage-dependent sodium and T-type calcium channels; may enhance GABAergic inhibition; inhibits carbonic anhydrase weakly. Reduces neuronal membrane instability and prevents abnormal seizure firing. Hepatically metabolized (CYP3A4); renally excreted. Good oral bioavailability in dogs and cats. Key information Anticonvulsant — sulfonamide derivative. Avoid in sulfa-sensitive animals. Monitor hepatic and renal function. Fewer drug interactions than phenobarbital. Store at room temperature.

Oral capsules: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. or without. Capsules may be opened and mixed into food if needed. Administer at consistent times. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Do not abruptly discontinue.

CNS: sedation, ataxia, vomiting (most common; usually transient). GI: anorexia, vomiting, diarrhea. Hepatotoxicity (rare — monitor liver enzymes). Renal tubular acidosis (rare). Urolithiasis (CA inhibition component). Skin reactions (rare hypersensitivity). Cats: metabolize more slowly — longer half-life and potential toxicity.

For animals Monitor liver enzymes with prolonged use. Reduce dose or extend interval in renal impairment. Sulfonamide derivative — avoid in sulfonamide-hypersensitive patients. Drug interaction: hepatic enzyme inducers (phenobarbital, rifampin) reduce zonisamide levels. Cats: longer half-life than dogs — monitor closely for accumulation and toxicity. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Anticonvulsant — Wash hands thoroughly with soap and water after handling. after handling. Sulfonamide derivative: inform doctor if sulfa-allergic. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact. Keep out of reach of children.

Contact your veterinarian. Zonisamide overdose causes sedation, ataxia, and GI signs. Supportive care.