Zovirax

Acyclovir antiviral for herpetic infections; equine and feline herpesvirus applications. Acyclovir antiviral cream/ointment (acyclovir). Mechanism: phosphorylated by viral thymidine kinase → acyclovir triphosphate inhibits viral DNA polymerase → chain termination. Topical formulation for skin/mucous membrane herpesvirus infections. Minimal systemic absorption. Key information Acyclovir — see acyclovir entry. Limited oral bioavailability in horses. Primarily used in birds and exotics.

Apply topically to affected area; wear gloves during application. Apply thin layer 5 times daily to affected lesion. Ophthalmic ointment: apply 1 cm ribbon to lower conjunctival sac 5 times daily. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one. Complete the course.

Topical: mild local irritation, burning, stinging. Drying effect on skin. Systemic absorption minimal from topical use. Contact dermatitis (rare hypersensitivity). Systemic adverse effects only relevant to IV/oral formulations (not topical).

For animals Topical antiviral — for external/ophthalmic use. Poor oral bioavailability in horses. Ensure adequate hydration with IV formulations. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Avoid inhaling sprays or aerosols. Keep out of reach of children. Antiviral topical — generally safe. Wash hands thoroughly with soap and water after handling. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. Acyclovir overdose causes kidney damage. Aggressive hydration required.