General Drug Information and Indications

Tepoxalin (dual COX/LOX inhibitor NSAID) for osteoarthritis pain and inflammation in dogs. Dual COX/LOX inhibitor NSAID (tepoxalin). Mechanism: inhibits both cyclooxygenase (COX-1 and COX-2) AND lipoxygenase (5-LOX) pathways → reduces both prostaglandins and leukotrienes → broad anti-inflammatory spectrum. Oral rapidly-dissolving tablet (REDI-TAB) for dogs. Broad anti-inflammatory coverage including leukotriene-mediated pathways. Key information Tepoxalin — dual COX/5-LOX inhibitor NSAID. Dogs only. Administer with food. Do not use with other NSAIDs or corticosteroids. Monitor renal and hepatic function. Store at room temperature.

How to Give this Medication

Oral rapidly-dissolving tablet (dogs): place on tongue — dissolves quickly without water. Administer with food or immediately after feeding. Once daily. Store at room temperature; protect from light. If a dose is missed Administer as soon as you remember. If it is almost time for the next scheduled dose, skip the missed dose and resume the normal schedule. Never double up doses to make up for a missed one.

Side Effects

GI: vomiting, diarrhea, gastric ulceration. Renal: azotemia. Hepatotoxicity. Platelet inhibition (COX-1 component). Do not combine with other NSAIDs or corticosteroids. Same profile as other dual COX/LOX inhibitor NSAIDs.

Precautions

For animals Monitor for GI ulceration; use with caution in animals with GI disease. Monitor renal function, hydration status, and urine output. Do not use concurrently with other NSAIDs or corticosteroids. Dual COX/LOX inhibitor. Not approved for use in food-producing animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). NSAID — Wash hands thoroughly with soap and water after handling. after handling. Keep out of reach of children.

Overdose

Contact your veterinarian immediately. NSAID overdose causes GI ulceration and kidney injury. Contact your veterinarian, a veterinary emergency clinic, or the ASPCA Animal Poison Control Center (888-426-4435) immediately. Do not induce vomiting unless specifically directed by a veterinary professional.

Zubrin 20 Ct dosage forms

ProductStrengthFormSizeType
ZUBRIN 20 CT 200 MG TABLET: TEPOXALIN200 MGTablet1Commercial
ZUBRIN 60 CT 200 MG TABLET: TEPOXALIN200 MGTablet1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual – Nonsteroidal Anti-inflammatory Drugs in Animals (https://www.merckvetmanual.com/pharmacology/inflammation/nonsteroidal-anti-inflammatory-drugs-in-animals); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)