General Drug Information and Indications

Tildipirosin (long-acting macrolide) for bovine respiratory disease; single-dose injectable. Long-acting macrolide antibiotic (tildipirosin). Mechanism: binds 50S ribosomal subunit at multiple sites → inhibits protein synthesis (bacteriostatic). Exceptionally high lung tissue concentrations (>100× plasma) maintained for >2 weeks after single IM injection. Selective lung tropism via drug transporter-mediated concentration. Key information Tildipirosin — macrolide for BRD in cattle. Single injection. Beef withdrawal: 21 days. Do not use in calves to be processed as veal.

How to Give this Medication

IM injection: administer deep IM in the neck. Single dose. Maximum injection volume per site varies by species. Store at room temperature; protect from light. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Side Effects

Injection site reactions (similar to other macrolides — persistent swelling/nodule). GI: decreased feed intake. Rare: anaphylaxis. Prolonged withdrawal times for food animals.

Precautions

For animals Observe food animal withdrawal times for milk and meat. Not for use in veal calves. Injection site reaction expected. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Macrolide injectable — wear gloves. Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Overdose

Contact your veterinarian. Tildipirosin is a single-injection product. Contact vet if dosing error occurred.

Zuprevo 100ml dosage forms

ProductStrengthFormSizeType
ZUPREVO 100ML 180MG/ML INJECTABLE: TILDIPIROSIN180 MG/MLInjectable1Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)