Zycortal

Desoxycorticosterone pivalate (DOCP) injectable for mineralocorticoid replacement in dogs with Addison's disease. Desoxycorticosterone pivalate (DOCP) injectable mineralocorticoid. Mechanism: pure mineralocorticoid receptor agonist (no glucocorticoid activity) → promotes Na+ reabsorption and K+ excretion in distal nephron → replaces aldosterone deficiency in Addison's disease. Pivalate ester depot injection provides 25-day duration. FDA-approved for dogs. Key information Desoxycorticosterone pivalate (DOCP) — mineralocorticoid for Addison's disease. Subcutaneous injection. Refrigerate. Lifelong therapy in Addison's patients. Monitor electrolytes and clinical signs monthly. Administer every 25–28 days.

SQ injection: administer SQ. Shake well before each use. well before use (oil-based suspension). Inject into loose skin (scruff or lateral thorax). Administer every 25 days initially; adjust interval based on electrolyte monitoring. Store at room temperature; protect from light. If a dose is missed This product is given as a single dose or as part of a defined protocol. Contact your veterinarian if a scheduled administration was missed. Zycortal is given every 25–28 days — contact your veterinarian to schedule the next injection.

Inadequate dosing → Addisonian crisis (hyponatremia, hyperkalemia, weakness, vomiting, shock). Excessive dosing → sodium/water retention, edema, hypertension, hypokalemia. Injection site reactions. Monitor electrolytes and clinical response every 25–30 days.

For animals Monitor electrolytes (Na+, K+) every 25–30 days. Adjust interval based on clinical signs and electrolytes — not on ACTH stimulation test. Supplement glucocorticoid (prednisolone) concurrently for glucocorticoid replacement in Addison's disease. Not approved for use in food-producing animals. For people handling this medication Wear gloves when handling. Wash hands thoroughly with soap and water after handling. Mineralocorticoid injectable — wear gloves. Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Keep out of reach of children. Pregnant women and women of childbearing age should avoid contact.

Contact your veterinarian. DOCP overdose causes sodium retention, potassium loss, and elevated blood pressure. Electrolyte monitoring required.