Zylexis Injectable

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General Drug Information and Indications

Parapoxvirus ovis immunostimulant for non-specific immune stimulation in horses; adjunct for respiratory infections. Parapoxvirus ovis (inactivated) immunostimulant. Mechanism: killed paramunity inducer — stimulates innate immune system (NK cells, macrophages) via TLR3/7 signaling → produces interferon-gamma, IL-2, and other cytokines → non-specific immunostimulation for 1–3 weeks. IM injection; for prophylaxis before stress events in horses. Key information Parapoxvirus ovis (PPVO) immunostimulant for horses. Refrigerate. IV injection. Shake well. Used for upper respiratory disease and stress conditions.

How to Give this Medication

IM injection: administer deep IM. Administer 4, 2, and 0 days before anticipated stress event. Store refrigerated (2–8°C); do not freeze. If a dose is missed This medication is administered by a veterinarian or veterinary staff in a clinical setting. Missed doses are managed by your veterinary team — contact your veterinarian to reschedule.

Side Effects

Injection site reactions (pain, swelling). Fever, lethargy (24–48 hrs post-injection — immune stimulation expected). Anaphylaxis (rare). Generally well tolerated.

Precautions

For animals Administer 4–8 days before anticipated stress event for optimal immune stimulation. Not approved for use in food-producing animals. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Immunostimulant vaccine — Injectable — administered by veterinary staff only. Wash hands thoroughly with soap and water after handling. If accidentally self-injected, seek emergency medical attention immediately. Wash hands thoroughly with soap and water after handling.

Overdose

Contact your veterinarian. PPVO immunostimulant overdose causes transient fever and injection-site reaction.

Zylexis Injectable dosage forms

ProductStrengthFormSizeType
ZYLEXIS INJECTABLE—Injectable—Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)