General Drug Information and Indications

Alpha-casozepine (bovine milk protein hydrolysate) supplement for anxiety, stress, and behavioral issues in dogs and cats; non-sedating anxiolytic. Bovine milk hydrolysate supplement (alpha-casozepine). Mechanism: tryptic digest of bovine alpha-s1-casein produces alpha-casozepine peptide → binds GABA-A/benzodiazepine receptor → mild anxiolytic effect (comparable to diazepam mechanism at low doses, without sedation). Oral capsules/powder; natural anxiolytic for stress-related behavioral issues. Key information Alpha-casozepine — calming nutraceutical. Store at room temperature. Administer with food or directly. Safe for daily use. No known drug interactions. Non-sedating.

How to Give this Medication

Oral capsules or powder: Administer orally. May be given with food to improve compliance and reduce GI upset. Administer with food to reduce GI adverse effects. Capsules may be opened and mixed into wet food. Administer once daily. Store at room temperature; protect from light. If a dose is missed Give the missed dose as soon as you remember. If you forget a day, simply resume the normal schedule the next day. Missing an occasional dose of this supplement is unlikely to cause harm.

Side Effects

Generally very safe. GI: mild, transient diarrhea or flatulence (rare). No significant adverse effects documented at recommended doses. Milk-derived — avoid in animals with documented cow milk protein allergy.

Precautions

For animals Dairy-derived — avoid in animals with documented cow milk protein allergy. May take 1–2 weeks for behavioral effect. Generally safe for long-term use. For people handling this medication Wash hands thoroughly with soap and water after handling. Avoid contact with eyes; if contact occurs, flush with water for 15 minutes and seek medical attention. Keep out of reach of children. If accidental ingestion occurs, contact Poison Control (1-800-222-1222). Milk protein supplement — generally safe. Avoid if known cow milk protein allergy. Wash hands thoroughly with soap and water after handling.

Overdose

Overdose with this supplement is unlikely to cause serious harm at slightly elevated doses, but contact your veterinarian if a large excess was given or if your animal shows any unusual signs. Alpha-casozepine is a milk protein derivative — very low toxicity.

Zylkene dosage forms

ProductStrengthFormSizeType
ZYLKENE 2000MG POWDER PKT: ZYLKENE2000 MGPowder—Commercial
ZYLKENE POWDER - 8GM8 GMPowder—Commercial

Sources

This information is provided for educational purposes and is not a substitute for advice from your veterinarian. Source: Merck Veterinary Manual (merckvetmanual.com); Plumb's Veterinary Drug Handbook (Plumb, D.C., app.plumbs.com)